Cortical influences drive amyotrophic lateral sclerosis
نویسندگان
چکیده
منابع مشابه
Cortical influences drive amyotrophic lateral sclerosis.
The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand prese...
متن کاملDouble cortical stimulation in amyotrophic lateral sclerosis.
OBJECTIVE Transcranial double magnetic stimulation on the motor cortex was used to investigate central motor tract function in 16 patients with amyotrophic lateral sclerosis, five with spinal muscular atrophy, and 16 age matched normal controls. METHODS Surface EMG responses were recorded from the relaxed abductor pollicis brevis (APB) muscle. RESULTS Responses to test stimuli were markedly...
متن کاملAltered cortical communication in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a disorder associated primarily with the degeneration of the motor system. More recently, functional connectivity studies have demonstrated potentially adaptive changes in ALS brain organization, but disease-related changes in cortical communication remain unknown. We recruited individuals with ALS and age-matched controls to operate a brain-computer inter...
متن کاملFrontotemporal cortical thinning in amyotrophic lateral sclerosis.
BACKGROUND AND PURPOSE The extensive application of advanced MR imaging techniques has undoubtedly improved our knowledge of the pathophysiology of amyotrophic lateral sclerosis. Nevertheless, the precise extent of neurodegeneration throughout the central nervous system is not fully understood. In the present study, we assessed the spatial distribution of cortical damage in amyotrophic lateral ...
متن کاملThe Cortical Signature of Amyotrophic Lateral Sclerosis
The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were a...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2017
ISSN: 0022-3050,1468-330X
DOI: 10.1136/jnnp-2017-315573